怀孕并发症与父亲心血管风险的关联:回顾性队列研究
Joseph Mussa1, Lingsheng Wen1, Mona Sharafi1
1Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
Journal of epidemiology and community health
|December 17, 2025
概括
妇女的不良妊娠结果,如妊娠期糖尿病和妊娠前,与父亲心脏代谢疾病风险增加有关. 这表明伴侣怀孕史可以识别需要早期心血管疾病预防策略的男性.
科学领域:
- 心血管健康的心血管健康
- 生殖健康 生殖健康
- 公共卫生 公共卫生
背景情况:
- 心血管疾病 (CVD) 风险检测在男性中具有挑战性.
- 孕期糖尿病,孕期高血压和妊娠前是女性已知的风险指标.
- 这项研究调查了不良妊娠结果是否也表明父亲由于共同的环境和行为因素而存在心血管疾病风险.
研究的目的:
- 为了确定母亲的不良妊娠结果是否与父亲心脏代谢疾病风险增加有关.
- 探索使用伴侣怀孕史来早期识别男性心血管疾病风险的潜力.
主要方法:
- 加拿大北克省415,730名父亲的回顾性队列研究,至少有两次单独分娩.
- 基于人口的卫生行政数据,出生,死胎和死亡登记册的分析.
- 通过使用Cox比例危险模型,研究了母亲累积妊娠糖尿病,妊娠高血压和妊娠前发生情况以及糖尿病,高血压和心血管疾病的新父亲诊断之间的联系.
主要成果:
- 伴侣患有妊娠糖尿病或孕前的父亲患糖尿病的风险增加 (在三次或更多次出现时增加高达84%) 和高血压 (增加高达39%).
- 在伴侣有两次或多次不良妊娠后果的父亲中,观察到心血管疾病的风险增加了15%.
- 显而易见的是剂量反应关系,更多的孕产妇不良妊娠结果与更高的父亲心脏代谢疾病风险相关.
结论:
- 妇女的不良妊娠结果与她们的男性伴侣心脏代谢疾病风险显著增加有关.
- 伴侣的怀孕史是识别男性患糖尿病,高血压和心血管疾病等疾病风险较高的宝贵工具.
- 利用伴侣怀孕史可以促进早期干预和预防策略,促进男性心血管健康.
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