在基本高血压患者中,尿酸对亚临床器官损伤的预测性性能分析
Luigi Petramala1, Gioacchino Galardo2, Francesco Circosta2
1Department of Translational and Precision Medicine, "Sapienza" University of Rome, Italy.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|December 17, 2025
概括
血清尿酸 (SUA) 和SUA/eGFR比率的升高与高血压中早期器官损伤有关,甚至低于传统的高尿血症水平. 肥胖增加了SUA,但削弱了其对心血管风险的预测能力.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 代谢综合征是代谢综合征的一种.
背景情况:
- 血清尿酸 (SUA) 是一个新兴的心血管风险标志物.
- 在SUA水平低于传统高尿路血症值时,风险增加.
- 在高血压中SUA,功能,器官损伤和肥胖之间的联系尚不清楚.
研究的目的:
- 为了将SUA和SUA/eGFR比率与高血压介导的器官损伤相关联.
- 为了研究这些相关性跨不同程度的脂肪在基本高血压患者.
主要方法:
- 研究了326名患有基本高血压的成年患者,按BMI分层.
- 使用心声学和实验室分析评估目标器官损伤 (LVMI,白膜尿).
- 根据验证的SUA截止值 (心血管死亡率为5.6 mg/dL) 分类患者.
主要成果:
- 随着BMI (p < 0.001) 的增加,SUA和SUA/eGFR增加.
- 超过5.6mg/dL的SUA比例从35.8% (正常体重) 增加到60.3% (肥胖).
- SUA和SUA/eGFR都与LVMI和白蛋白尿相关 (p < 0.01),正常体重患者的心脏重塑预测最强.
结论:
- 升高的SUA和SUA/eGFR与高血压的早期心脏和脏变化有关,即使低于高尿素水平.
- 肥胖会增加SUA,但会降低其对器官损伤的独立预测值.
- 建议在高血压患者的风险评估中使用较低的,以心血管为重点的SUA值和SUA/eGFR.
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