定量性肺颗粒物分析链接增加的人类性色素负担燃烧坑暴露在9/11后的退伍军人与遥远的肺部疾病
Jeremy T Hua1,2,3,4, Lauren M Zell-Baran5,6, Carlyne D Cool7
1Division of Environmental and Occupational Health Sciences, National Jewish Health, Denver, CO, USA. huaj@njhealth.org.
Scientific reports
|December 17, 2025
概括
暴露在燃烧坑烟雾中的退伍军人可能会患上肺部疾病. 由于这些暴露而产生的炭粉尘与退伍军人的部署相关的远部肺部疾病 (DDLD) 有关.
科学领域:
- 环境健康 环境健康
- 肺部医学 肺部医学
- 毒理学 毒理学 毒理学
背景情况:
- 在西南亚和阿富汗的军事部署涉及危险的空中暴露.
- 识别导致部署相关的远端肺部疾病 (DDLD) 的特定毒素是具有挑战性的.
研究的目的:
- 量化DDLD的退伍军人,呼吸道支气管炎 (RB) 的吸烟者和健康对照中的肺颗粒物.
- 调查肺部颗粒物与部署暴露之间的关联.
主要方法:
- 用于肺组织的颗粒物定量显微镜 (QM-PM) 技术.
- 分析有色素 (人科菌) 和双裂颗粒 (二氧化/酸盐).
- 24名退伍军人患有DDLDD,10名吸烟者患有RB和10名健康对照之间的比较.
主要成果:
- 与健康对照人群相比,患有DDLDD的退伍军人显示出较高的人类性色素分数,类似于RB吸烟者.
- 退伍军人中较高的色素分数与报告的燃烧坑烟雾暴露相关.
- 在RB吸烟者中观察到双断层尘埃密度的增加,而不是在DDLDD退伍军人或对照组中.
结论:
- 燃烧暴露于烟雾中的人类毒性尘埃的肺部沉积可能导致9/11后的退伍军人中DDLD病原体.
- 燃烧坑的烟雾是部署退伍军人的DDLD的一个重要因素.
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