在早产婴儿死亡性肠球炎后的成长结果趋势,跨越营养习惯的变化
Lan-Wan Wang1,2,3, Chi-Hsiang Chu4, Yung-Chieh Lin5
1Department of Pediatrics, Chi Mei Medical Center, Tainan, Taiwan.
极度早产的婴儿患有第二阶段死性肠球炎 (NEC) 实现了追赶增长. 然而,那些患有第三阶段NEC的人,尽管营养改善,但头部生长缺陷仍然存在.
科学领域:
- 新生儿科学 新生儿科学
- 儿科胃肠病学 儿科胃肠病学
- 营养科学 营养科学
背景情况:
- 研究患有死性肠球炎 (NEC) 的极度早产婴儿的生长结果至关重要.
- 了解不断变化的营养习惯对这些脆弱婴儿的影响至关重要.
研究的目的:
- 分析极度早产婴儿与NEC的产后和出院后生长趋势.
- 评估随着时间的推移,营养习惯的变化如何影响基于NEC严重性的生长结果.
主要方法:
- 一项多中心队列研究包括3046名怀孕28周前 (2006-2019) 出生的婴儿.
- 从NICU出院到24个月的校正年龄,分析了生长轨迹 (zBW,zHC).
- 倾向-分数匹配 (PSM) 用于在NEC严重程度 (没有/第一阶段,第二阶段,第三阶段) 和三个时代 (2006-2019) 中比较婴儿.
主要成果:
- 患有II/III期NEC的婴儿在晚期出院时具有较低的zBW和zHC.
- 第二阶段NEC婴儿在6-24个月时达到可比体重和头部生长.
- 第三阶段NEC婴儿在12-24个月后体重上升,但头部生长缺陷持续.
结论:
- 患有II期NEC的婴儿表现出追赶增长,表明对营养进步的积极反应.
- 第三阶段NEC始终面临挑战,长达24个月的持续头部生长赤字.
- 营养实践改善了结果,但对于严重的NEC可能需要具体的干预措施来优化神经发育轨迹.
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