在子宫内暴露于RAAS抑制剂后产后和长期结果:基于德国索赔数据的队列研究
Tania Schink1, Malte Braitmaier2, Katarina Dathe3
1Department of Clinical Epidemiology, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany. schink@leibniz-bips.de.
Pediatric nephrology (Berlin, Germany)
|December 17, 2025
概括
在怀孕20周后,胎儿暴露于氨酸- ангиотензин- алдостерон系统抑制剂 (RAAS-I) 可能导致胎儿病变,而血管激素II受体阻断剂 (ARB) 的风险更高. 像高血压这样的长期结果可能会在几年后出现.
科学领域:
- 产周医学 产周医学
- 药学流行病学 药学流行病学
- 儿科病学 儿科病学
背景情况:
- 列宁- ангиотензин- алдостерон系统抑制剂 (RAAS-I) 在怀孕晚期禁用.
- 虽然已知RAAS-I胎儿病变,但暴露后的长期结果尚不清楚.
- 这项研究调查了胎儿RAAS-I暴露的产后和长期健康影响.
研究的目的:
- 评估20周妊娠后RAAS-I相关胎儿病变的风险.
- 评估在子宫内暴露于RAAS-I的儿童的长期结果,包括高血压和病.
- 为了比较RAAS-I和推的抗高血压 (HYP) 暴露之间的结果.
主要方法:
- 使用了德国制药流行病学研究数据库 (GePaRD),其中包括20%的德国人口.
- 包括在怀孕20周后暴露于RAAS-I或HYP (甲醇,甲基多巴) 的怀孕.
- 在出生后180天内评估RAAS-I胎内病的诊断,并检查长期健康记录.
主要成果:
- 确定了203名暴露于RAAS-I和29674名暴露于HYP的活产婴儿.
- 在3.9%的新生儿中发生了RAAS-I胎内病变 (11.5%的ARB),而在HYP中则没有.
- 在没有胎儿病的儿童中,暴露于RAAS-I的1.5%患有高血压或接受抗高血压药物,而暴露于HYP的0.6%.
结论:
- ангиотензин II 受体阻断剂 (ARBs) 与 ACE 抑制剂相比,对胎儿病的风险更高.
- 胎儿RAAS-I暴露的长期后果,如高血压,可能在出生后几年出现.
- 持续监测子宫内RAAS-I暴露的儿童是合理的.
关键词:
抗胰岛素II型1受体抑制剂 (ARBs) 是一种抗胰岛素II型1受体抑制剂.ангиотензин转化酶 (ACE) 抑制剂 抑制剂与药物相关的副作用和不良反应长期的结果 长期的结果怀孕 怀孕 怀孕 怀孕雷宁血管胺阿尔多斯特系统抑制剂更多相关视频
05:13Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
Published on: February 28, 2025
573
07:36Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
11.7K
相关概念视频
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
380
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
380
Teratogenicity
3.9K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
3.9K
