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Updated: Jan 8, 2026

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
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Published on: September 28, 2022

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一种非典型的非核糖体环酶,可催化同体性合与循环氨基核的核

Mitsuo Aono1, Yuito Yamada1, Kenichi Matsuda2

  • 1Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.

The Journal of antibiotics
|December 17, 2025
PubMed
概括

这项研究揭示了momomycin cyclase (MmmB-TE) 如何使用罕见的二次氨基核为宏环化. 脊柱N-甲基化增强了这种非核糖体 (NRP) 的循环效率.

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