年龄作为决定性因素的决策在老年患者与HER2阳性和三阴性乳腺癌的年龄
Daniel Otero-Romero1, Laura Medina-Mora2, Rubén Carramiñana-Nuño2
1General and Digestive Surgery Department, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain. danieloteroromero@gmail.com.
European geriatric medicine
|December 17, 2025
概括
年代年龄,而不是健康状况,往往决定了老年女性的乳腺癌治疗. 这种年龄歧视导致治疗不足,特别是对于激进的三阴性和HER2阳性类型.
科学领域:
- 在瘤学瘤学.
- 老年医学 老年医学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 老年女性的乳腺癌发病率正在上升.
- 在这个人口群体中,关于攻击性亚型 (三阴性,HER2阳性) 的数据有限.
研究的目的:
- 评估时间表年龄是否会影响患有侵袭性乳腺癌的老年妇女的治疗决策.
- 评估伴随性疾病和麻醉风险与年龄在治疗选择中的作用.
主要方法:
- 对70岁以上的三阴性或HER2阳性乳腺癌妇女进行了回顾性观察研究 (2014-2024年).
- 收集的临床,瘤和治疗数据.
- 评估并发症 (查尔森并发症指数) 和麻醉风险 (ASA分类).
- 治疗不足被定义为没有使用NCCN推的疗法.
- 使用后勤回归来识别治疗决策的预测因素.
主要成果:
- 在129名年龄≥70.1的患者中,58.1%观察到治疗不足.
- 在80岁以上的患者中,治疗不足接近普遍水平.
- 时间学年龄是省略哨兵淋巴结活检,化疗,抗HER2疗法和放射治疗的主要因素.
- 年龄的影响独立于并发症,麻醉风险或瘤阶段.
结论:
- 时间学年龄显著,而且往往不成比例地影响了老年妇女患有侵袭性乳腺癌的治疗决策.
- 这种年龄偏差有助于高风险人群的治疗不足和健康不平等.
- 老年人评估工具对于确定适合指南一致治疗的候选人以及确保个性化护理至关重要.
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