在小鼠中,S100B触发神经内分泌巨细胞网络,驱动呼吸道再生
Bing Sun1, Haiting Dai1, Tiemei Zhao2
1State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Nature communications
|December 17, 2025
概括
结合蛋白S100B对于肺部修复至关重要,因为它有助于肺部神经内分泌细胞在受伤后再生. 这种S100B-arginase-1通路增强了巨细胞和上皮细胞之间的通信,以有效修复呼吸道.
科学领域:
- 肺部医学 肺部医学
- 细胞生物学 细胞生物学
- 免疫学 免疫学 免疫学
背景情况:
- 哺乳动物的呼吸道上皮具有专门用于伤害反应的细胞.
- 协调上皮质修复的机制尚未完全理解.
- 肺神经内分泌细胞 (PNEC) 作为哨兵,可以支持再生.
研究的目的:
- 研究S100B在呼吸道修复过程中维持PNEC干细胞特性中的作用.
- 为了阐明参与PNEC介导的肺再生的信号通路.
主要方法:
- 研究了S100B表达和功能,以应对上皮损伤.
- 研究了S100B,巨细胞 (阿基因酶-1) 和PNECs之间的相互作用.
- 使用胺胺和蛋白激酶p110-alpha信号调节的S100B活性.
主要成果:
- 在受伤后,S100B表达在PNEC中被诱导,对于它们的干细胞状性质至关重要.
- 释放的S100B参与了阿尔金酶-1表达巨细胞,促进PNEC扩张和过渡到再生细胞.
- 改变S100B活动会影响PNECs的再生能力.
结论:
- 确定了一种新型的S100B-arginase-1信号轴,该轴控制了肺修复中的巨细胞-上皮细胞通信.
- 在呼吸道再生过程中,S100B是PNEC功能的关键调节者.
- S100B代表了促进肺部修复的潜在治疗标.
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