评估系统性炎症和基于营养的指数,用于预测HPV持续性
Fatma Ozmen1, Burcu Ozata2, Burcu Erol2
1Department of Gynecological Oncology, Ordu University School of Medicine, Training and Research Hospital, Ordu, 52000, Turkey. dr.fatmaozmenkaya@gmail.com.
BMC women's health
|December 17, 2025
概括
中性粒细胞与淋巴细胞的比率 (NLR) 显示出预测人类乳头瘤病毒 (HPV) 一年持久性的潜力,与其他炎症标志物不同. HPV16和HPV18感染与持续性HPV有很强的联系,这凸显了需要更好的风险分层标志物.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 持续高风险的人类乳头瘤病毒 (HPV) 感染,特别是HPV16和HPV18,是导致子宫癌的主要原因.
- 系统性炎症和营养指数,如HALP和PNI是恶性瘤的预后,但它们在HPV持续性中的作用尚不清楚.
研究的目的:
- 评估血红蛋白,白蛋白,淋巴细胞和血小板 (HALP) 评分和预后营养指数 (PNI) 的预测价值,以确定HPV持续时间为一年.
- 评估其他炎症标志物:中性粒细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR) 和C反应蛋白 (CRP) 来预测HPV持续性.
主要方法:
- 对470名HPV阳性女性进行了至少一年的回顾性研究.
- 收集了基线人口统计,临床,组织病理学和实验室数据.
- 计算的HALP和PNI得分;评估的NLR,PLR和CRP. 使用ROC分析和多变量后勤回归评估预测性能.
主要成果:
- 42.3%的女性在一年后患有持续性HPV感染.
- HALP,PNI,PLR和CRP没有显示出对HPV持久性的显著区分能力.
- 持久性组的NLR显著高于持久性组,显示出适度的区分能力 (AUC=0.623).
- HPV16和HPV18阳性与持续性有很强的相关性.
结论:
- HALP,PNI,PLR和CRP并不是HPV持续一年的有效预测指标.
- 作为一种简单的系统性炎症标志物,NLR显示出预测HPV持续性的前景.
- HPV16和HPV18与持续感染有显著的关联,支持它们的免疫逃避机制.
- 需要对结合粘膜免疫和全身炎症的预后标志物进行进一步的研究,以更好地分层风险.
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