晚期肺癌炎症指数与肺癌患者手术后死亡率之间的关联:一个回顾性队列研究
Lingzi Su1, Xi Li2, Qilin Yang3
1Department 1 of Oncology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China.
European journal of medical research
|December 17, 2025
概括
先进的肺癌炎症指数 (ALI) 预测了肺癌手术后的死亡率. 较低的ALI得分与更高的90天内死亡风险,180天内死亡风险和住院期间死亡风险相关.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 生物标志物 生物标志物
背景情况:
- 肺癌仍然是癌症死亡的主要原因之一.
- 早期非小细胞肺癌 (NSCLC) 的手术切除在生存率和不良结果方面存在局限性.
- 先进的肺癌炎症指数 (ALI) 整合了BMI,白蛋白和中性粒细胞与淋巴细胞的比率 (NLR) 来评估患者的状况.
研究的目的:
- 在接受肺癌切除的患者中评估术前高级肺癌炎症指数 (ALI) 的预后价值.
- 确定ALI和肺癌手术后的短期死亡率之间的关联.
主要方法:
- 对2447名接受肺癌切除术的患者进行了回顾性队列研究.
- 先进的肺癌炎症指数 (ALI) 在手术前使用BMI,白蛋白和NLR计算.
- 多变量回归分析评估了ALI与90天,180天和住院死亡率之间的关系.
主要成果:
- 低ALI得分的患者年龄较大,实验室分析较差.
- 与高ALI组相比,低ALI组的90天,180天和住院死亡率显著更高.
- 高的ALI得分与90天 (HR 0.18) 和180天 (HR 0.30) 死亡率的风险大大降低,以及住院死亡率的几率降低 (OR 0.34).
结论:
- 先进的肺癌炎症指数 (ALI) 是肺癌切除后临床预后不佳的重要预测指标.
- 较低的ALI值与90天,180天和住院死亡率的增加密切相关.
- 在手术肺癌患者的预后评估中,ALI作为一种有价值的工具.
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