含有蛋白质的纳米系统:从基础到应用
Abhishek Baral1, Subhasish Roy2
1Department of Chemistry, Sister Nivedita University, DG Block, Action Area I, 1/2, Newtown, Kolkata, West Bengal, 700156, India.
Chemistry, an Asian journal
|December 17, 2025
概括
蛋白质结合纳米粒子为诊断和药物输送提供先进的纳米医学解决方案. 本综述详细介绍了它们的制备,应用和对theranostics的生物相互作用.
科学领域:
- 纳米医学和生物材料科学
背景情况:
- 蛋白质结合纳米粒子 (NP) 在纳米生物医学中对于诊断,药物输送和探针至关重要.
- 基于蛋白质的纳米材料显示,由于增强的生物吸收和清除,它们对theranostics具有前途.
研究的目的:
- 审查创建稳定的蛋白质-NP结合物的方法.
- 讨论蛋白质-NP合物在纳米医学中的应用.
- 突出NP对蛋白质结构的影响以及蛋白质-NP冠状病毒的意义.
主要方法:
- 对共价和非共价结合策略的审查.
- 在NP相互作用时分析蛋白质构造,折叠,纤维化和聚合.
- 检查蛋白质-NP冠状在纳米复合材料功能中的作用.
主要成果:
- 通过共价和非共价方法可以制备各种稳定的蛋白质-NP合物.
- NP影响蛋白质构成,可能影响生物活性.
- 蛋白质-NP冠状体对于纳米复合材料的性能至关重要.
结论:
- 蛋白质结合的NP是用于theranostics和其他纳米医学应用的多功能平台.
- 了解NP-蛋白相互作用对于设计有效的纳米生物材料至关重要.
- 新兴的纳米材料,如无金属蛋白NP和纳米集群,扩大了治疗可能性.
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