MTHFR和ABCB1多态因子与血液性恶性瘤患者的毒性相关,这些患者接受高剂量甲甲酸盐治疗
Yaling Shi1, Nan Zhou1, Lu Cao1
1Department of Pharmacy, ShaanXi Provincial People's Hospital, 256 Youyixi Road, Beilin District, Xi'an, ShaanXi Province, China.
Scientific reports
|December 17, 2025
概括
在MTHFR和ABCB1的基因变异影响血液癌症患者高剂量甲状腺素毒性. 年龄和MTHFR 1298AC是延迟药物消除的关键因素,有助于个性化治疗策略.
科学领域:
- 药物基因组学 药物基因组学
- 在瘤学瘤学.
- 临床药理学 临床药理学
背景情况:
- 高剂量甲状腺素 (HD-MTX) 对于血液性恶性瘤至关重要,但会导致毒性.
- 药物代谢酶的遗传变异 (多态) 可能会影响MTX的疗效和毒性.
- 之前对MTHFR C677T,MTHFR A1298C和ABCB1 C3435T多态性和MTX毒性的研究尚未得出结论.
研究的目的:
- 为了研究MTHFR C677T,MTHFR A1298C和ABCB1 C3435T基因多态性和HD-MTX相关的毒性和血液性恶性瘤的成年患者的延迟消除之间的关联.
- 确定延迟MTX消除的独立风险因素.
主要方法:
- 分析了接受HD-MTX的111名患有血液性恶性瘤的成年患者队列.
- 对MTHFR C677T,MTHFR A1298C和ABCB1 C3435T多态性进行了基因定型.
- 使用统计分析来评估多形态,临床因素,MTX毒性和消除之间的关系.
主要成果:
- 在这组患者中,MTHFR C677T,MTHFR A1298C和ABCB1 C3435T基因多态性与MTX相关的毒性显著相关.
- 年龄 (≥60岁) 和MTHFR A1298C多态性被确定为延迟MTX消除的独立风险因素.
- 这些发现表明MTX毒性和药物清除变化的遗传倾向.
结论:
- MTHFR C677T,MTHFR A1298C和ABCB1 C3435T多态性在患有血液性恶性瘤的患者的MTX毒性和消除中发挥作用.
- 识别具有特定多态性和年龄较大的患者可以帮助预测和管理延迟的MTX消除.
- 这些遗传标记物为个性化HD-MTX治疗提供了潜在的潜力,以减轻毒性并改善患者的治疗结果.
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