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cGAS通过抑制多ADP-ribosylation来限制PARP1-介导的微同质介导的末端结合

Haibo Yang1, Boya Gao2, Bo Wu3

  • 1Department of Urology, Brigham and Women's Hospital & Harvard Medical School, Boston, MA, USA.

Cell death and differentiation
|December 17, 2025
PubMed
概括

循环GMP-AMP合成酶 (cGAS) 抑制DNA修复通路,促进基因组的稳定性. 前列腺癌细胞中cGAS的丧失增加了对PARP1的依赖,提高了对PARP抑制剂的敏感性.

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