在绝经后的女性乳腺癌后乳腺癌特异性死亡率和心血管疾病特异性死亡率的种族差异
Kerryn W Reding1,2, Alexi L Vasbinder3, Richard K Cheng4
1School of Nursing, University of Washington, Box 357266, 1959 NE Pacific Street, WA, 98195, Seattle, USA. kreding@uw.edu.
Cardio-oncology (London, England)
|December 18, 2025
概括
患有乳腺癌 (BC) 的黑人女性面临更高的BC死亡率,这对生存差异作出了重大贡献. 然而,心血管疾病 (CVD) 死亡率在白人女性中更高,突出了结果中的复杂种族差异.
科学领域:
- 在瘤学瘤学.
- 心血管医学 心血管医学
- 健康差距 研究 研究 研究 研究
背景情况:
- 乳腺癌 (BC) 死亡率的种族差异得到了充分记录,特别是影响黑人女性.
- 心血管疾病 (CVD) 死亡率对患有BC的黑人女性生存差距的具体贡献尚不清楚.
研究的目的:
- 调查心血管疾病 (CVD) 死亡率在乳腺癌 (BC) 幸存者中观察到的种族差异中的作用.
- 为了比较心血管事件的发生率,心血管疾病死亡率和BC死亡率,在被诊断患有BC的黑人和白人妇女之间.
主要方法:
- 分析了来自8410名侵袭性乳腺癌 (BC) 幸存者在妇女健康倡议 (WHI) 队列中的数据.
- 计算心血管 (CV) 事件,心血管疾病死亡率和BC死亡率的10年累积发病率,按种族分层.
- 利用精细和灰色的竞争风险模型来计算分分布危险比率 (sHR).
主要成果:
- 与白人女性相比,黑人女性经历了较高的非致命CV事件的10年累积发病率 (10.9%vs8.2%) 和BC死亡率 (15.3%vs11.5%).
- 白人女性10年内心血管疾病死亡率较高 (7.2%对10.1%).
- 与白人女性 (20%) 相比,黑人女性 (35%) 的乳腺癌死亡率占总死亡率的比例更高.
结论:
- 在乳腺癌 (BC) 存活率方面,种族差异仍然存在,主要是由于黑人女性的BC死亡率.
- 未来的BC死亡率减少可能会将重点转移到心血管疾病死亡率的差异上,因为心血管疾病事件和结果存在种族差异.
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