持续吸烟会增加扩散型大B细胞淋巴瘤的死亡率,但不是毛囊淋巴瘤,芬兰基于人口的研究表明
Taina Reunamo1, Erika Alanne2, Toni Mikkola3
1Turku University Hospital and University of Turku, Department of Oncology, Turku, Finland; Wellbeing services county of Southwest Finland, Turku, Finland. taina.reunamo@varha.fi.
Acta oncologica (Stockholm, Sweden)
|December 18, 2025
概括
持续吸烟与扩散性大B细胞淋巴瘤 (DLBCL) 患者的存活率较差有关,但不是毛囊淋巴瘤 (FL). 戒烟支持对于改善DLBCL的结果至关重要.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 烟草吸烟在B细胞淋巴瘤的预后作用是在rituximab前时代确立的.
- 它与现代治疗,分期,亚型和在扩散大B细胞淋巴瘤 (DLBCL) 和卵泡淋巴瘤 (FL) 中的生存结果的关联需要进一步调查.
研究的目的:
- 为了研究吸烟状态对DLBCL和FL患者在现代治疗中生存结果的影响.
- 为了确定吸烟是否仍然是这些淋巴瘤亚型的独立预后因素.
主要方法:
- 来自图尔库和坦佩雷大学医院的DLBCL和FL患者的回顾性分析 (2009-2019).
- 从电子医疗记录中提取人口,瘤,分期和治疗数据.
- 利用基于深度学习的自然语言处理算法来提取吸烟状态.
- 计算了卡普兰-梅尔总生存率 (OS) 估计和调整的危险比率 (HRs).
主要成果:
- 总共有1,258名DLBCL和529名FL患者被纳入,随访时间中位数为96个月.
- 在DLBCL中,5年后的生存率为61% (从未),53% (前) 和45% (持续吸烟者). 持续吸烟是较短寿命的独立预后因素 (HR 1.27).
- 在佛罗里达州,没有根据吸烟状态观察到OS的显著差异,五年OS率约为74%-79%. 吸烟者在诊断时更年轻,在全身疗法使用中没有观察到差异.
结论:
- 与从未吸烟者相比,持续吸烟与DLBCL患者的死亡率增加有关.
- 吸烟似乎不会影响FL患者的生存结果.
- 预防吸烟和戒烟支持是改善DLBCL患者结果的关键干预措施.
相关概念视频
01:25Statistical Methods for Analyzing Epidemiological Data
864
Epidemiological data primarily involves information on specific populations' occurrence, distribution, and determinants of health and diseases. This data is crucial for understanding disease patterns and impacts, aiding public health decision-making and disease prevention strategies. The analysis of epidemiological data employs various statistical methods to interpret health-related data effectively. Here are some commonly used methods:
864
02:20Longitudinal Research
13.0K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.0K
01:21Cancer Survival Analysis
629
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
629
02:59Cancer Prevention
7.6K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
7.6K