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产前COVID-19疫苗接种与新生儿结果之间的关联

Napatsorn Thewaran¹, Wasin Laohavinij¹, Surasith Chaithongwongwatthana²

¹Department of Preventive and Social Medicine.

Journal of patient safety

|December 18, 2025

概括

孕妇在怀孕期间接种COVID-19疫苗,特别是mRNA疫苗,与降低死产和怀孕年龄小 (SGA) 率有关. 在第二或第三个三个月内接种疫苗进一步改善了新生儿结局,支持孕妇疫苗的安全性.

科学领域:

产科和妇科产科和妇科
疫苗学疫苗学疫苗学
新生儿健康新生儿健康

背景情况:

COVID-19疫苗对于控制大流行病至关重要.
关于孕妇疫苗安全性的错误信息仍然存在,特别是在异种疫苗接种计划的情况下.
研究母体COVID-19疫苗接种后的新生儿结果是必不可少的.

研究的目的:

评估孕妇在怀孕期间接种COVID-19疫苗和关键新生儿结果之间的关联.
为了解决围绕孕妇群体COVID-19疫苗接种的安全问题.
为公共卫生建议提供基于证据的信息.

主要方法:

对4032名孕妇进行回顾性队列研究 (2021年9月至2023年12月).
收集关于人口统计,疫苗接种情况 (包括类型和时间) 以及新生儿结局的数据.
使用描述性统计和物流回归的统计分析.

主要成果:

怀孕期间的COVID-19疫苗接种与明显较低的死产率 (aOR:0.41) 和较小的妊娠年龄 (SGA) (aOR:0.27) 相关.
在第二或第三个三个月内接种疫苗与减少堕胎,死产,SGA和低的5分钟Apgar分数相关.
与没有接种疫苗相比,mRNA疫苗的流产和死产率较低.

结论:

孕妇在怀孕期间接种COVID-19疫苗与新生儿不良结果的增加无关.
疫苗接种与死亡出生和SGA的发病率降低有关.
随着后期三个月的疫苗接种和充分的疫苗接种状态观察到的有利关联支持COVID-19疫苗在怀孕期间的安全性和有效性.

关键词:

接种COVID-19疫苗的时间孕产妇健康孕产妇健康新生儿的结果.怀孕怀孕怀孕怀孕怀孕过早出生过早出生一个死产的死产.

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