运动诱导的代谢重编程和免疫调节:癌症治疗的新策略
Anqi He1, Tianjie Bao1, Shunzi Rong2
1Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, Key Laboratory of Rehabilitation Medicine in Sichuan Province, West China Hospital, Sichuan University, Chengdu, 610041, China.
Exercise immunology review
|December 18, 2025
概括
定期运动通过改变代谢途径和增强免疫细胞活性来重编程瘤代谢和免疫力. 这种非药理学方法显示了改善癌症治疗的前景.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 代谢过程中的代谢.
- 运动科学 运动科学
背景情况:
- 运动是一种有力的非药物干预,影响癌症生物学.
- 身体活动影响全身和瘤特异性代谢网络.
- 运动调节瘤微环境中的先天性和适应性免疫反应.
研究的目的:
- 审查癌症中运动诱导的代谢和免疫重编程的分子和系统机制.
- 探索运动如何重塑瘤微环境 (TME).
- 概述瘤学中运动干预的临床转化策略.
主要方法:
- 通过运动激活的分子信号通路的审查,包括AMPK-mTOR-HIF1α,PGC-1α-ERRα和IL-6/STAT3.
- 分析运动引起的全身和瘤代谢变化 (葡萄糖,乳酸,氨基酸,脂质).
- 检查运动对免疫细胞透和功能 (T细胞,NK细胞) 和肌释放 (IL-6,IL-15,素,SPARC) 的影响.
主要成果:
- 运动重编代谢通路,增强代谢灵活性,减少免疫抑制代谢物.
- 运动通过肌分泌和改善血管化促进抗瘤免疫力,导致免疫细胞透率增加.
- 运动激活了关键的信号网络,这些信号网络整合了新陈代谢和免疫功能.
结论:
- 运动显著重编程瘤代谢和免疫格局,提供一种非药物治疗策略来对抗癌症.
- 运动干预措施,特别是精确的处方,可以提高化疗和免疫治疗的疗效.
- 进一步的临床转化是有必要的,以优化基于运动的癌症疗法.
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