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可降解的多功能微球用于肝细胞癌的联合热疗法-栓塞-免疫激活疗法

Xuepeng Lv¹, Mingxi Ma¹, Zhaoyang Zhao²

¹State Key Lab of Digital Medical Engineering Jiangsu Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, P. R. China.

Advanced healthcare materials

|December 18, 2025

概括

一种新型可降解栓塞微球 (RegFe@MS) 装载着regorafenib和氧化铁纳米颗粒有效治疗肝癌. 这种方法通过抑制血管生成和跨动脉化血栓化 (TACE) 后的残留瘤生长来抑制瘤复发.

科学领域:

生物医学工程生物医学工程
在瘤学瘤学.
材料科学材料科学材料科学

背景情况:

跨动脉化学栓塞 (TACE) 是对不可切除的肝细胞癌 (HCC) 的首要治疗方法.
在TACE后的HCC中,瘤复发通常是由血管内皮生长因子A (VEGF-A) 的升高调节和由于缺氧的血管生成引起的.
目前针对VEGF或VEGFR的抗血管性单一疗法在治疗HCC方面有效性有限.

研究的目的:

设计和评估一种新的可降解栓塞微球 (RegFe@MS),用于HCC中联合化学栓塞和抗血管生成.
研究RegFe@MS在抑制栓塞后血管新生和残留瘤进展方面的疗效.
评估RegFe@MS在*in vivo*肝癌模型中的治疗潜力.

主要方法:

使用"双液相连续药物加载技术"开发RegFe@MS,以封装regorafenib和磁性氧化铁纳米粒子.
通过轻度高温症来评估RegFe@MS抑制缺氧诱导因子1-alpha (HIF-1α) 和C-C化学因子受体6型 (CCR6) 的能力.
评估持续局部释放regorafenib以抑制VEGFR及其治疗效果在子正型肝癌模型.

主要成果:

RegFe@MS有效加载了regorafenib和纳米颗粒,证明了受控释放.
轻度高温症与RegFe@MS抑制HIF-1α上调和CCR6表达,抑制VEGF-A释放.
从RegFe@MS中持续释放regorafenib抑制了VEGFR,抑制了血管生成,并减少了残留瘤的增殖和入侵.
在子正型肝癌模型中,RegFe@MS显示出显著的治疗效果.

结论:

RegFe@MS通过同时解决栓塞和抗血管生成,为HCC治疗提供了一个有前途的策略.
这种双重作用的方法有效地抑制TACE后瘤复发和残留瘤生长.
RegFe@MS证明了肝癌的显著治疗潜力,需要进一步的临床研究.

关键词:

肝细胞癌是肝细胞癌.磁性高热疗法是一种磁性高热疗法.这些微球是微球.雷戈拉芬尼布的使用情况通过动脉的化学栓塞.

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