纤维细胞激活蛋白抑制剂 (FAPI) - 在评估非瘤性疾病中的放射性质PET/CT:叙述性审查
Forough Kalantari1,2, Anton Amadeus Hörmann1, Martha Pokarowski3
1Division of Molecular Imaging and Theranostics, Department of Nuclear Medicine, University Hospital, Paracelsus Medical University, Salzburg 5020, Austria.
ACS pharmacology & translational science
|December 18, 2025
概括
纤维细胞激活蛋白成像 (FAPI PET/CT) 显示出对诊断和监测各种非癌症疾病,包括纤维细胞和心血管疾病的可能性. 需要进一步的研究来证实其有效性超出目前的小型研究.
科学领域:
- 核医学就是核医学.
- 分子成像学分子成像学
- 放射化学 放射化学是指辐射化学.
背景情况:
- 纤维细胞激活蛋白 (FAPI) 越来越多地被认为具有超越瘤学的作用.
- 目前的研究正在探索非瘤应用的FAPI PET/CT和PET/MRI,以补充或潜在地超越2-[18F]-FDG成像.
- FAPI成像为各种非瘤疾病中的分子成像提供了一个有前途的途径.
研究的目的:
- 审查FAPI PET/CT和PET/MRI在非瘤性疾病中的良性发现和应用.
- 在各种非瘤领域探索FAPI标记物的潜力.
- 概述FAPI成像在非瘤疾病中的未来方向.
主要方法:
- 临床和临床前研究的叙事综述.
- 在非瘤环境中对FAPI PET/CT和PET/MRI现有文献的分析.
- 使用2-[18F]-FDG进行FAPI成像的比较.
主要成果:
- FAPI PET/CT和PET/MRI显示出成像纤维化疾病,心血管疾病,炎症/传染病,骨疾病,神经成像和器官移植的潜力.
- FAPI 标记器可以识别和监测非瘤性疾病.
- 目前的证据主要来自小型的回顾性研究和案例报告.
结论:
- 针对非瘤疾病的定向成像和监测,FAPI放射性对象具有前景.
- 在非瘤性疾病中应用FAPI PET/CT是一个越来越感兴趣的领域.
- 前性研究对于确定可靠的结论和临床实用性至关重要.
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