通过调节氧化应激,TRAP1在胃癌细胞中诱导了对青的抗性
Zhenglei Ji1, Lu Liu1, Jingya Chen1
1School of Public Health, Bengbu Medical University, Bengbu, Anhui, China.
Frontiers in molecular biosciences
|December 18, 2025
概括
瘤亡因子受体相关蛋白1 (TRAP1) 通过减少氧化应激和细胞死亡,降低胃癌中西斯丁 (CDDP) 的敏感性. 向TRAP1可能会提高CDDP化疗的疗效.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 胃癌 (GC) 是癌症死亡的主要原因之一.
- 西斯普拉丁 (CDDP) 是一种关键的化疗药物,但耐药性限制了它的有效性.
- 瘤亡因子受体相关蛋白1 (TRAP1) 在GC药物耐药性中的作用尚不清楚.
研究的目的:
- 研究TRAP1在调节GC细胞对CDDP敏感性的作用.
- 确定TRAP1是否影响CDDP诱导的氧化应激.
- 评估TRAP1作为克服CDDP耐药性的潜在治疗点.
主要方法:
- 在GC组织中TRAP1表达的生物信息分析和预后.
- 已建立的GC细胞模型与TRAP1过度表达和沉默.
- 测量反应性氧物种 (ROS),线粒体膜潜力 (MMP),DNA损伤和CDDP治疗后的细胞死亡与/或没有N-乙-L-氨酸 (NAC).
主要成果:
- 在GC组织中,TRAP1被上调,并与预后不佳有关.
- 在接受CDDP治疗的GC细胞中,TRAP1降低了ROS,稳定了MMP,并减轻了DNA损伤,减少了细胞死亡.
- 过度表达TRAP1增强了NAC的保护作用;沉默TRAP1抵消了它们.
结论:
- 通过减少氧化应激诱导的细胞死亡,TRAP1减弱了GC中的CDDP敏感性.
- TRAP1是一种潜在的生物标志物和治疗瘤治疗的治疗标.
- 针对TRAP1提供了一种提高CDDP化疗疗效率的策略.
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