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Updated: Jan 8, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
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由MSL复合体对CD274/PD-L1的表观遗传激活扩大了其作用,超出了剂量补偿的范围

Aiping Wen1, Xuanfei Feng2, Yingying Li1

  • 1Department of Gynecology and Obstetrics, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.

Frontiers in immunology
|December 18, 2025
PubMed
概括

男性特异性致死性 (MSL) 复合体,特别是MSL1,通过组织素乙化直接激活CD274 (PD-L1) 转录. 这一发现揭示了调节免疫检查点的新表观遗传机制,并为癌症免疫治疗提供了潜在的标.

关键词:
CD274 是一个CD274H4K16AcAc 在线阅读基因组乙烯转移酶 (Histone Acetyltransferase) 是一种酶.这是一种男性特异性的致命性致命性.转录规则 转录规则 转录规则

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