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肺腺癌中PPP2R1A的表达特征,预后价值和与免疫相关的分析

Shanshan Xiao^1,2, Yuhong Hu², Yawen Li²

¹Obstetrics and Gynecology Department, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China.

Frontiers in immunology

|December 18, 2025

概括

蛋白酸酶2调节子单元Aα (PPP2R1A) 在肺腺癌 (LUAD) 中上调,与预后不佳相关. 它的抑制抑制了LUAD细胞生长和转移,表明其作为生物标志物和治疗点的潜力.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
癌症研究癌症研究

背景情况:

肺腺癌 (LUAD) 由于预后不佳,因此具有重大临床挑战.
蛋白酸酶2调控子单元Aα (PPP2R1A) 在LUAD瘤发生中的确切作用和临床意义在很大程度上仍未确定.

研究的目的:

为了研究PPP2R1A在LUAD中的表达模式,诊断潜力和预后价值.
阐明在LUAD中PPP2R1A的分子机制和免疫微环境的关联.
实验验证PPP2R1A在LUAD进展中的功能作用.

主要方法:

在LUAD中分析PPPP2R1A表达,使用TCGA数据和西安学术在线.
通过ROC,Kaplan-Meier和Cox回归分析评估诊断和预后意义.
探索分子功能,蛋白相互作用,免疫透,并通过基因敲除和基于细胞的测试进行实验验证.

主要成果:

在LUAD组织中,PPPP2R1A显著上调,具有适度的诊断潜力 (AUC=0.593).
高PPP2R1A表达与不良的无进展和整体存活率,晚期瘤阶段和结节转移相关.
在体外,抑制PPP2R1A显著抑制了LUAD细胞的增殖,迁移和入侵.

结论:

在LUAD中,PPP2R1A过度表达,并充当瘤基因,驱动恶性表型.
PPP2R1A 影响关键信号通路和 LUAD 中的瘤免疫微环境.
PPP2R1A是一个有前途的预后生物标志物,也是LUAD治疗的潜在治疗标.

关键词:

卡普兰 - 梅尔策划者这就是PPP2R1A.免疫透免疫透是什么?肺部腺癌瘤是什么瘤微环境是一个微环境.

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