ROX指数与败血症患者死亡率的关联:一项回顾性研究
Jiali Wu1, Jing Zhao1, Xiaojing Ji2
1Department of Emergency, General Hospital of Ningxia Medical University, Yinchuan, China.
Frontiers in medicine
|December 18, 2025
概括
在败血症患者中,较高的ROX指数与降低死亡率和更短的住院时间有关. 该指数显示28天死亡率的预测准确度中等,超过SOFA得分.
科学领域:
- 关键护理医学 关键护理医学
- 呼吸系统生理学 呼吸系统生理学
- 败血症研究 败血症研究
背景情况:
- 败血症是一个重大的全球健康挑战,需要改进的预后工具.
- 衡量呼吸功能的ROX指数在评估败血症严重程度方面具有潜在的实用性.
研究的目的:
- 调查ROX指数与败血症患者的临床结果之间的关联.
- 评估ROX指数对死亡率和停留时间的预测准确度.
主要方法:
- 从MIMIC-IV数据库对23,502名败血症患者的回顾性分析.
- 利用受限立方线和考克斯回归模型来评估ROX指数关联.
- 将ROX指数的预测性能与28天死亡率的SOFA得分进行比较.
主要成果:
- 较高的ROX指数层与较低的28天,7天和14天死亡率显著相关.
- 观察到一个"L"形的关联,死亡风险在ROX指数10.50.0附近平稳.
- 对于最短的ICU和住院时间,确定了最佳ROX指数值,ROX指数显示出中等的预测准确性 (AUC=0.63).
结论:
- ROX指数是预测败血症患者的结果的一个有价值的工具.
- 较高的ROX指数值与更好的生存率和更短的住院时间相关.
- ROX指数为预测败血症结果提供了一个潜在的优越替代SOFA得分.
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