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通过楼层废水分析追踪与年龄相关的抗生素耐药性模式

Anna Pico-Tomàs^1,2, Alejandro Sanchís¹, Cristina Mejías-Molina^3,4

¹Catalan Institute for Water Research (ICRA-CERCA), Girona 17003, Spain.

ACS ES&T water

|December 18, 2025

概括

废水分析揭示了抗菌素耐药性 (AMR) 基因的年龄相关差异. 学校的废水具有最多的抗性基因,而老年护理设施显示出最高的多样性,影响公共卫生战略.

科学领域:

环境微生物学环境微生物学
公共卫生公共卫生
基因组学就是基因组学.

背景情况:

抗菌素耐药性 (AMR) 是一个日益增长的全球健康威胁.
了解多样化的城市人口中的AMR对于有效的监测至关重要.
基于废水的流行病学 (WBE) 提供了一种在特定社区监测AMR的方法.

研究的目的:

通过使用建筑层WBE,研究抵抗体和运动体的特定年龄变异.
为了在不同的人口环境中比较细菌群体,抗生素耐药性基因 (ARG) 和移动遗传元素 (MGE).
确定与城市人口中AMR相关的潜在公共卫生风险.

主要方法:

从小学,大学宿舍和老年护理机构取楼层废水样本.
基因组测序用于分析细菌群落,ARG和MGE.
统计分析以确定细菌属和ARG之间的相关性.

主要成果:

观察到与年龄相关的ARG丰度和多样性的显著变化.
小学废水的ARG含量最高;老年护理机构的ARG多样性最高.
细菌病原体在学校和老年护理机构的样本中更为普遍,肠道微生物群是ARG的主要储存库.

结论:

局部化WBE与元基因组学相结合,可以揭示人口特异性的AMR模式.
调查结果为针对性AMR监测和干预策略提供了可行的证据.
肠道微生物群在抗生素耐药性的传播中发挥着重要作用.

关键词:

根据年龄组的不同.抗微生物耐药性 (AMR) 是一种移动ome是一个移动ome.通过被动抽样进行抽样.抗体ome 抗体ome 抗体ome 抗体ome 下水道下水道下水道基于废水的流行病学 (WBE)

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