在西藏羊 (Pantholops hodgsonii) 中的胚囊炎感染改变了肠道微生物群的组成和功能
Jian Liu1,2,3, Si-Yuan Qin4, Cong-Cong Lei4
1Guangxi Key Laboratory of Brain and Cognitive Neuroscience, College of Basic Medicine, Guilin Medical University, Guilin, Guangxi, China.
Frontiers in cellular and infection microbiology
|December 18, 2025
概括
胚囊ST31感染显著改变了西藏的肠道微生物群. 这种寄生虫可能会通过减少有益的微生物和损害肠道功能来阻碍高海拔适应.
科学领域:
- 微生物组研究的研究.
- 寄生虫学的寄生虫学
- 野生动物生态学野生动物生态学
背景情况:
- 肠道微生物群对于宿主适应和病原体防御至关重要.
- 寄生虫感染可以破坏肠道微生物群落,影响宿主适应能力.
- 有限的数据存在于来自极端环境的野生哺乳动物中的寄生虫-微生物群相互作用.
研究的目的:
- 研究肠道寄生虫感染对藏肠道微生物群的影响.
- 为了确定特定的胚囊亚型及其与微生物社区转移的关联.
- 了解这些变化如何影响藏对高海拔环境的适应能力.
主要方法:
- 分析 68 个来自西藏羊的肠道元基因组.
- 查布拉斯托菌,克里普托斯菌,吉亚迪亚菌和脑菌的感染.
- 肠道微生物群的组成和功能概况,包括LEfSe和KEGG分析.
主要成果:
- 在26个个体中发现了细胞囊亚型ST31,显著改变了肠道微生物的组成.
- 感染导致了微生物多样性的减少以及像Arthrobacter sp.这样的高原适应性微生物的丰富性. 08Y14. 在 08Y14. 在 08Y14.
- 功能分析显示,感染个体的代谢能力降低,CAZy家族较少,KEGG通路发生变化.
结论:
- 胚囊体ST31感染重塑了西藏的肠道微生物群.
- 观察到的微生物和功能变化可能会损害该物种的高海拔适应能力.
- 这项研究为来自极端环境的野生哺乳动物的胚胎细胞诱导的肠道微生物群变化提供了新的见解.
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