在接受健康检查的人群中,研究甲状腺结节与METS-IR和SII的相关性
Ruoping Guan1, Guokui Dai1, Chuanjiang Ye2
1Clinical Laboratory, Guangzhou Cadre and Talent Health Management Center, Guangzhou, China.
Frontiers in endocrinology
|December 18, 2025
概括
甲状腺结节很常见,特别是在女性和老年人中. 胰岛素耐药性 (METS-IR) 和炎症 (SII) 可能有助于评估结节风险,低级结节与TSH相反相关.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 生物标志物研究 生物标志物研究
背景情况:
- 甲状腺结节非常普遍,影响超过60%的成年人.
- 影响甲状腺结节发育和风险分层的因素对于临床管理至关重要.
研究的目的:
- 检查甲状腺结节与两个新生物标志物之间的关联:胰岛素抵抗代谢评分 (METS-IR) 和全身免疫炎症指数 (SII).
主要方法:
- 一项回顾性横截面研究分析了49835名接受健康检查的成年人的数据.
- 甲状腺结节使用甲状腺成像报告和数据系统 (TI-RADS) 类别进行分类.
- 通过包括后勤回归在内的统计分析,评估了结节患病率,性别,年龄,TSH,METS-IR和SII之间的关系.
主要成果:
- 在60.12%的参与者中检测到甲状腺结节,女性患病率更高,年龄越来越大.
- TI-RADS 2和3结节显示与TSH水平的反向关联.
- TI-RADS 3和≥4结节与METS-IR和SII的升高积极相关.
结论:
- 甲状腺结节很常见,特别是在女性和老年人中.
- METS-IR和SII可以作为评估甲状腺结节风险的有价值的生物标志物.
- 该研究强调了代谢和炎症标志物与甲状腺结节特征之间的潜在联系.
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