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动物模型中的中风后发作:系统性审查和元分析

Kayla D L Csernyanszki¹, Nmazule K Nyenke-Wofuru¹, McKenzee M Olsen¹

¹Department of Social Sciences, Augustana Faculty, University of Alberta, Camrose, AB, Canada.

Frontiers in neuroscience

|December 18, 2025

概括

脑卒中后发作 (PSS) 会增加神经损伤. 这次审查发现PSS与焦性缺血模型中的较大病变有关,但不是ICH,方法上的缺陷限制了研究结果.

科学领域:

神经科学是一个神经科学.
脑卒中研究脑卒中研究
的研究研究.

背景情况:

脑卒中后发作 (PSS) 是一种常见的中风并发症.
在临床前中风模型中对PSS的研究有限.
在动物模型中了解PSS对于翻译研究和治疗至关重要.

研究的目的:

在动物模型中系统地审查和元分析PSS发生率和后果.
在缺血性中风 (IS) 和脑内出血 (ICH) 模型中评估PSS研究的方法质量.
在临床前研究中评估PSS和中风结果之间的关系.

主要方法:

在Embase,Medline,Scopus和Web of Science进行系统搜索.
包括同行评审的动物研究 (1999年以后) 报告了没有干预的发作和结果.
进行了数据提取,偏差风险评估和随机效应分析,以检测损伤体积.

主要成果:

10项研究符合标准;8项符合元分析的条件. 发作发生率各不相同 (17.5-82%的焦点缺血,45-67%的ICH).
分析:发作与焦性缺血中较大的病变相关 (赫奇的G=1.598,p=0.038),而不是ICH (赫奇的G=0.180,p=0.468).
在研究中发现偏差的高风险;确定了方法上的局限性,表明出版偏差.

结论:

缺乏严格的临床前PSS研究,存在显著的异质性.
与焦点缺血相关的发作与较大的病变和更严重的神经缺陷有关.
未来的研究需要严格的长期研究,标准化的监测和多样化的人口.

关键词:

动物模型动物模型脑内出血脑内出血缺血性中风中风损伤的体积,损伤的体积.神经系统缺陷神经系统缺陷在中风后发作.

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