在癌症治疗中应用MOFs介导的光疗
Mengyu Xu1, Liyuan Wang2, Yuanxin Chen1,3
1Central Laboratory, Linyi People's Hospital, School of Clinical Medicine, Shandong Second Medical University Shandong China wanglj730@163.com zhu-yanxi@163.com.
RSC advances
|December 18, 2025
概括
金属有机框架 (MOFs) 对癌症光疗有很大的希望,增强光动力学 (PDT) 和光热 (PTT) 治疗. 它们独特的特性使得有效的药物输送和有针对性的治疗具有降低的毒性.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 在瘤学瘤学.
背景情况:
- 传统的癌症光疗材料在结构设计和可调性方面存在局限性.
- 金属有机框架 (MOFs) 提供了诸如高表面积,多孔性和可定制的活性站点等优势.
- MOF正在成为先进治疗应用的有希望的纳米载体.
研究的目的:
- 系统地审查MOFs在癌症光疗中的最新进展.
- 突出MOF在光动力学疗法 (PDT) 和光热疗法 (PTT) 中的潜力.
- 讨论基于MOF的多模式治疗策略,以改善癌症治疗.
主要方法:
- 将光敏感剂加载到MOF中,以增强PDT的活性氧物种 (ROS) 生成.
- 使用MOF作为光敏感材料,以改善ROS生产.
- 针对性修改MOFs以提高瘤特异性.
- 将贵金属纳米粒子或新型连接体系统集成到MOF中,用于近红外光吸收和转化在PTT中.
主要成果:
- 在PDT中,MOF显著提高了ROS生成效率.
- MOF 显示出 PTT 极好的近红外光吸收和转换.
- 基于MOF的多式联络治疗策略越来越复杂.
- MOF为开发高效,低毒性纳米光疗系统提供了一个可行的平台.
结论:
- 由于其可调节的特性,MOFs为癌症光疗提供了一个多功能平台.
- MOF增强了PDT和PTT的疗效,为癌症治疗提供了新的途径.
- 以MOF为媒介的多式疗法代表了未来癌症纳米医学的一个有希望的方向.
相关概念视频
02:49Cancer Therapies
9.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.8K
02:57Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K
02:56Treatment Resistant Cancers
3.7K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.7K