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相关概念视频

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
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相关实验视频

Updated: Jan 8, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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在全身性硬化症中循环中升高的互白素-17水平:元分析.

Young Ho Lee1, Gwan Gyu Song1

  • 1Division of Rheumatology, Department of Internal Medicine, Anam Hospital, Korea University College of Medicine, Seoul, Korea.

Journal of rheumatic diseases
|December 18, 2025
PubMed
概括

这次元分析发现,虽然系统性硬化症 (SSc) 患者和对照人群之间整体介质素-17 (IL-17) 水平没有差异,但像IL-17A这样的特定亚型在SSc中显著升高,这表明它在疾病发病过程中发挥了作用.

科学领域:

  • 免疫学 免疫学 免疫学
  • 类风湿病学 类风湿病学
  • 生物化学 生化学

背景情况:

  • 系统性硬化症 (SSc) 是一种复杂的自身免疫性疾病,其特征是纤维化和血管异常.
  • 介素-17 (IL-17) 是一种促炎性细胞因子,涉及各种自身免疫和炎症性疾病.

研究的目的:

  • 进行一项元分析,评估循环中介素-17 (IL-17) 水平与系统性硬化症 (SSc) 之间的关联.
  • 将SSc患者的IL-17水平与健康对照进行比较,并分析特定的IL-17亚型.

主要方法:

  • 在 MEDLINE,Embase 和 Web of Science 进行了系统的文献搜索.
  • 包括16项与1229名SSc患者和839名对照者的研究,比较了IL-17,IL-17A,IL-17B,IL-17E和IL-17F的血清/血水平.
  • 根据种族和疾病亚型进行了子组分析.

主要成果:

  • 总体循环IL-17水平在SSc患者和对照人群之间没有显著差异 (SMD=0.260,p=0.825).
  • 然而,在SSc患者中,IL-17A,IL-17B,IL-17E和IL-17F水平显著升高 (所有患者p<0.05).
  • IL-17A表现出最明显的关联 (SMD=2.046,p=0.002). 在扩散和有限的SSc之间没有发现IL-17A的显著差异.
关键词:
细胞因子 (cytokines) 是一种细胞因子.炎症 炎症是一种炎症.介质蛋白-17 介质蛋白-17 介质蛋白进行元分析分析.系统性硬化症 系统性硬化症

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结论:

  • 特定的IL-17亚型,特别是IL-17A,IL-17B,IL-17E和IL-17F,在全身性硬化症中显著增加.
  • 这些发现表明,IL-17细胞因子,特别是IL-17A,在SSc.的病变发生中起着至关重要的作用.