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在全身性硬化症中循环中升高的互白素-17水平:元分析

Young Ho Lee¹, Gwan Gyu Song¹

¹Division of Rheumatology, Department of Internal Medicine, Anam Hospital, Korea University College of Medicine, Seoul, Korea.

Journal of rheumatic diseases

|December 18, 2025

概括

这次元分析发现,虽然系统性硬化症 (SSc) 患者和对照人群之间整体介质素-17 (IL-17) 水平没有差异,但像IL-17A这样的特定亚型在SSc中显著升高,这表明它在疾病发病过程中发挥了作用.

科学领域:

免疫学免疫学免疫学
类风湿病学类风湿病学
生物化学生化学

背景情况:

系统性硬化症 (SSc) 是一种复杂的自身免疫性疾病,其特征是纤维化和血管异常.
介素-17 (IL-17) 是一种促炎性细胞因子,涉及各种自身免疫和炎症性疾病.

研究的目的:

进行一项元分析,评估循环中介素-17 (IL-17) 水平与系统性硬化症 (SSc) 之间的关联.
将SSc患者的IL-17水平与健康对照进行比较,并分析特定的IL-17亚型.

主要方法:

在 MEDLINE,Embase 和 Web of Science 进行了系统的文献搜索.
包括16项与1229名SSc患者和839名对照者的研究,比较了IL-17,IL-17A,IL-17B,IL-17E和IL-17F的血清/血水平.
根据种族和疾病亚型进行了子组分析.

主要成果:

总体循环IL-17水平在SSc患者和对照人群之间没有显著差异 (SMD=0.260,p=0.825).
然而,在SSc患者中,IL-17A,IL-17B,IL-17E和IL-17F水平显著升高 (所有患者p<0.05).
IL-17A表现出最明显的关联 (SMD=2.046,p=0.002). 在扩散和有限的SSc之间没有发现IL-17A的显著差异.

结论:

特定的IL-17亚型,特别是IL-17A,IL-17B,IL-17E和IL-17F,在全身性硬化症中显著增加.
这些发现表明,IL-17细胞因子,特别是IL-17A,在SSc.的病变发生中起着至关重要的作用.

关键词:

细胞因子 (cytokines) 是一种细胞因子.炎症炎症是一种炎症.介质蛋白-17 介质蛋白-17 介质蛋白进行元分析分析.系统性硬化症系统性硬化症

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