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肝细胞癌中微RNA结合部位多态性:对病变发生,预后和治疗反应的影响

Sara Rezapour¹, Farin Khodam Mohammadi², Mahmoud Darweesh^3,4

¹Cancer Research Center, Institute of Cancer, Hamadan University of Medical Sciences, Hamadan, Iran, umsha.ac.ir.

International journal of genomics

|December 18, 2025

概括

微RNAs (miRNAs) 是肝细胞癌 (HCC) 发展和治疗反应的关键调节剂. 米RNA单核酸多态 (SNPs) 之间的相互作用为HCC诊断和个性化治疗提供了新的生物标志物.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学遗传学是一个

背景情况:

肝细胞癌 (HCC) 因其复杂的分子基础而带来了重大的全球健康挑战.
微RNAs (miRNAs) 是基因表达的关键调节者,影响与HCC相关的关键细胞过程.

研究的目的:

审查miRNAs在HCC病变发生,进展和治疗结果中的多方面的作用.
探索与miRNA相关的单核酸多态 (SNP) 对HCC脆弱性和发展的影响.
巩固关于miRNA-SNP相互作用的发现,与核心HCC支柱相关:细胞灭绝,DNA修复,免疫逃避和转移.

主要方法:

综合性文献综述,重点关注miRNA在HCC中的功能.
分析miRNA结合位点中的遗传变异 (SNP) 及其功能后果.
探索新兴的诊断和治疗技术,包括液体活检和外体miRNA分析.

主要成果:

在HCC中,MiRNAs显著影响着亡,DNA修复,免疫调节,血管生成,迁移,入侵和瘤进展.
在miRNA结合位点中的SNP可以改变miRNA-mRNA相互作用,影响与HCC相关的基因表达和细胞过程.
作为早期诊断,预后和治疗监测的非侵入性生物标志物,MiRNAs显示出希望.

结论:

密RNA-SNP相互作用代表了了解HCC病因和进展的新途径.
这些相互作用为HCC风险分层和个性化治疗策略提供了潜在的非侵入性遗传生物标志物.
新兴技术可能会通过miRNA分析彻底改变HCC的检测和管理.

关键词:

修复DNA的修复DNA的修复血管新生是因为血管新生.灭症 (apoptosis) 是一种死亡的过程.生物标志物生物标志物肝细胞癌是肝细胞癌.免疫调节免疫调节液体活检活检液体活检微RNAs 是一个微型RNA.精准医学是一门精准医学.单个核酸的多形态.

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MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...