一个药物流行病学指标,用于检测潜在的区域过度使用催眠药在日本:一个横截面研究
Ryosuke Shinkai1,2, Takashi Tomita3,1
1School of Pharmacy, International University of Health and Welfare (IUHW) - Narita Campus, Narita, JPN.
Cureus
|December 18, 2025
概括
环境和人口因素,如阳光持续时间和衰老率,影响区域催眠处方. 这项研究提出了一个指标来检测潜在的过度使用,特别是在城市地区,指导老年人优化使用.
科学领域:
- 药学流行病学 药学流行病学
- 环境健康 环境健康
- 老年病的医生 老年病的医生
背景情况:
- 循环时间相关的催眠药被广泛使用,特别是在老年人身上.
- 处方模式的区域差异表明环境和人口因素的影响.
- 检测潜在的过度使用对于优化药物管理至关重要.
研究的目的:
- 调查环境 (阳光持续时间,紫外线指数) 和人口 (老龄化率,诊所密度) 因素以及日本与昼夜相关的催眠药的区域处方模式之间的联系.
- 开发一个药物流行病学指标,以确定这些药物的潜在过度使用的地区.
- 探索催眠处方的地理差异.
主要方法:
- 全国范围内的生态横截面研究使用2022年来自47个县的日本数据.
- 对拉梅尔顿 (ramelteon),苏沃雷克桑 (suvorexant) 和勒莫雷克桑 (lemorexant) 的调整后人群处方量进行分析.
- 相关性和多变量线性回归,与地理可视化残余来识别异常值.
主要成果:
- 较短的阳光照射时间和更高的衰老率与增加的拉梅尔和苏沃雷克桑特的处方显著相关.
- 阳光持续时间和衰老速度独立地预测了处方量,解释了差异的很大一部分.
- 剩余分析表明,城市县的处方量高于预期,这表明局部处方趋势.
结论:
- 区域性催眠处方量可以部分由环境因素预测,如阳光持续时间.
- 开发的基于指标的框架可以帮助识别有过度使用催眠药的风险的地区.
- 这种方法支持开发气候敏感策略,以优化老年人群中催眠药的使用.
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