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疫苗诱导的甲状腺毒性病的罕见副作用:一个案例报告
Muhammad Munir1, Adnan Abdullah2, Gideon Mlawa3
1Geriatrics, Queen's Hospital, Romford, GBR.
Cureus
|December 18, 2025
概括
阿斯特拉泽内卡COVID-19疫苗接种可能引发新发格雷夫斯病,一种自身免疫性甲状腺疾病. 这份病例报告详细介绍了一名在接种疫苗后患上甲状腺功能障碍的患者,强调了临床意识的必要性.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 格雷夫斯病是一种自身免疫性甲状腺功能障碍,由甲状腺刺激激素受体抗体 (TRAb) 引起.
- 自免疫性甲状腺功能障碍与SARS-CoV-2感染和COVID-19疫苗接种有关.
- 需要对ChAdOx1 nCoV-19 (阿斯特拉泽内卡) 疫苗在新发动的格雷夫斯病中的潜在作用进行调查.
研究的目的:
- 在AstraZeneca的COVID-19疫苗接种后报告一个新出现的Graves'病例.
- 突出COVID-19疫苗接种与自身免疫性甲状腺疾病之间的潜在关联.
- 强调早期识别和管理疫苗相关的格雷夫斯病的重要性.
主要方法:
- 一个49岁的男性在接种疫苗后出现甲状腺功能过高症状的病例报告.
- 临床检查,实验室检测 (TSH,自由甲状腺素,TRAb) 和甲状腺超声波.
- 用碳醇,醇和皮质类固醇治疗,随访一年.
主要成果:
- 患者在接种第二剂AstraZeneca疫苗后大约两周出现了症状.
- 生物化学测试证实甲状腺功能障碍与TRAb水平升高.
- 治疗导致了临床和生化改善,持续的甲状腺功能减退,并在一年后降低了TRAb.
结论:
- 在AstraZeneca的COVID-19疫苗和新发作的Graves病之间存在潜在的联系.
- 临床医生应考虑在接种疫苗后出现甲状腺功能过高症状的患者中与疫苗相关的自身免疫甲状腺疾病.
- 及时诊断,适当的管理和长期随访对于管理疫苗接种后的格雷夫斯病至关重要.
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