腹部按摩调节失眠模型大鼠的肠道微生物群和脑肠
Junchang Liu1,2,3,4, Gulaisaer Aikebaier2, Xusheng Lu2,3,4
1The Fourth Clinical Medical College of Xinjiang Medical University, Ürümqi, China.
Frontiers in microbiology
|December 18, 2025
概括
腹部按摩通过调节肠道微生物群和脑肠来改善失眠的老鼠的睡眠时间. 这种传统中医技术显示出通过微生物群-肠-大脑轴来管理睡眠障碍的前景.
科学领域:
- 综合医学是一个整体的医学.
- 神经胃肠病学 神经胃肠病学
- 微生物组研究 微生物组研究
背景情况:
- 腹部按摩是一种中国传统医学治疗失眠的疗法.
- 它的精确机制,特别是关于微生物群-肠-大脑轴,尚未完全理解.
- 这项研究调查了腹部按摩对肠道微生物群和脑肠在失眠模型的影响.
研究的目的:
- 在大鼠模型中探索腹部按摩对失眠的治疗效果.
- 阐明肠道微生物群和脑肠在腹部按摩作用机制中的作用.
- 为了检查腹部按摩对微生物群-肠-大脑轴的影响.
主要方法:
- 在使用PCPA的Wistar大鼠中建立了一个失眠模型.
- 鼠被用腹部按摩或皮治疗了14天.
- 评估包括海马体组织病理学,血清脑肠水平 (ELISA) 和肠道微生物群组成 (16S rRNA测序).
主要成果:
- 在失眠模型中,腹部按摩显著增加了睡眠时间.
- 治疗缓解了海马的损伤,并调节了脑肠水平.
- 腹部按摩改变了肠道微生物群的组成,减少了Bacteroidetes和Proteobacteria,同时增加了Firmicutes和特定的有益细菌.
结论:
- 腹部按摩可以缓解失眠,并提高老鼠的睡眠时间.
- 治疗效果与大脑肠道和肠道微生物群的调节有关.
- 研究结果支持微生物群-肠-大脑轴作为腹部按摩治疗失眠的关键途径.
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