在糖尿病视网膜病变中促进体和5'UTR VEGF多态的病例控制研究
Diala Walid Abu-Hassan1, Muawyah D Al-Bdour2,3,4, Huda Tahir1
1Department of Physiology and Biochemistry, School of Medicine, The University of Jordan, Amman, Jordan.
概括
血管内皮生长因子 (VEGF) 促进体和特定单体类型的遗传变异与2型糖尿病患者患糖尿病视网膜病变 (DR) 的风险增加有关.
科学领域:
- 遗传学和眼科 医学
- 糖尿病学 糖尿病学
- 分子生物学分子生物学
背景情况:
- 糖尿病视网膜病变 (DR) 涉及由血管内皮生长因子 (VEGF) 介导的视网膜新血管化.
- 在患有增殖性糖尿病视网膜病变的患者的眼液中观察到VEGF水平升高.
- VEGF基因多态可能会影响对DR的敏感性.
研究的目的:
- 调查VEGF促进体/5'UTR多态和糖尿病视网膜病变 (DR) 的发展或严重程度之间的关联.
- 确定特定的VEGF遗传变异,使得2型糖尿病患者的DR风险.
主要方法:
- 一个病例控制研究,涉及有或没有DR的2型糖尿病患者和健康对照.
- 使用聚合酶链反应和限制片段长度多态度的VEGF促进子/5'UTR多态度的基因定型.
- 基于有或没有增殖性变化的DR的分类.
主要成果:
- 在糖尿病患者和对照患者之间,以及在DR和非DR糖尿病患者之间,发现了T{-1,498) C,G{-1,190) A和G{-1,154) A多态的基因型分布的显著差异.
- 没有发现DR严重程度与研究的多形态之间存在关联.
- 在DR患者中,CGGCC亚型最为普遍,而TGAGC,TGACT和CAGCT亚型在糖尿病患者中增加.
结论:
- 特定的VEGF多态和CGGCC单元型显著与2型糖尿病患者的DR风险增加有关.
- 这些遗传因素可能在糖尿病视网膜病变的发病过程中发挥作用.
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