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生命早期的逆境与灰色物质宏观结构和微观结构的发展之间的关联

Anders Lillevik Thorsen^1,2,3, Florence Friederike Boehmisch⁴, Dag Alnæs^5,6

¹Bergen Center for Brain Plasticity, Haukeland University Hospital, Bergen, Norway.

Psychological medicine

|December 18, 2025

概括

早期的生活逆境影响大脑发育. 父母的接受加速皮质稀薄,而虐待则会减缓儿童和青少年的微观结构发展.

科学领域:

神经科学是一个神经科学.
发展心理学发展心理学
脑部成像脑部成像

背景情况:

早期生活逆境 (ELA) 与儿童时期的大脑结构变化有关.
对于ELA对大脑发育轨迹的长期影响尚不清楚.

研究的目的:

调查ELA如何影响灰色物质宏观结构和微观结构的纵向发展.
检查特定ELA因素 (创伤,父母接受,虐待) 与大脑发育之间的关联.

主要方法:

利用了来自青少年大脑认知发展研究的6414名参与者的数据 (年龄为9-11岁,1923人跟随11-13岁).
采用线性混合效应模型来分析MRI衍生的纵向灰色物质测量 (皮层厚度,表面积,皮层下体积,T1w/T2w比率).
评估了大脑发育和创伤暴露,父母接受,家庭虐待以及创伤弹性/易感性之间的关系.

主要成果:

较高的父母接受度和创伤暴露与9-11岁的皮层较低厚度有关.
创伤敏感性与海马体积和皮质表面积负相关.
纵向来看,父母接受度的增加与皮层稀薄度的增加相关,而家庭虐待与T1w/T2w比率的变化较小相关.

结论:

父母的接受和创伤弹性与年轻人 (9-13岁) 的皮质稀释速度更快有关.
家庭滥用与较慢的微观结构发展有关,这表明T1w/T2w比率变化减少.
威胁和剥夺可能会在童年后期独特地影响灰色物质发育轨迹.

关键词:

大脑发育大脑的发育大脑的发展早期的生活逆境逆境灰色物质是一种灰色物质.宏观结构就是宏观结构.微观结构的微观结构一个创伤的创伤创伤.

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