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Updated: Jan 8, 2026

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用新型固相相容弹头捕获酶活动的基探针

Valerio Cataldi1, Nikita Ostrovitsa1, Fangyuan Cao2

  • 1School of Chemistry, Trinity Biomedical Sciences Institute, Trinity College Dublin, Pearse St., Dublin 152-160, Ireland.

ACS chemical biology
|December 18, 2025
PubMed
概括

我们开发了使用乙烯基甲基 (VME) 氨基酸的新型性探针,用于基于活动的强大的蛋白质概况. 这些探针对Otubain 1 (OTUB1) 具有很高的反应性和选择性,OTUB1是DNA修复和癌症中的关键酶.

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DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
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