每日调节的皮质和黑色素反向控制内毒素诱导的急性免疫反应
Montaser Haddad1, Sebastien Trzebanski1, Ramon Bossardi Ramos2
1Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.
European journal of immunology
|December 18, 2025
概括
午后用脂聚糖 (LPS) 挑战的小鼠因炎症的死亡率高于午夜挑战的小鼠. 像皮质和黑激素这样的环节性激素调节了败血症存活率的日常变化.
科学领域:
- 免疫学 免疫学 免疫学
- 时间生物学 时间生物学
- 内分泌学 在内分泌学.
背景情况:
- 对于内毒素挑战,生存的日间变化存在,但机制尚不清楚.
- 主体对感染的炎症反应受到昼夜节律的影响.
研究的目的:
- 调查败血症生存率日间变化的背后机制.
- 确定昼夜调节激素在调节对脂多糖 (LPS) 炎症反应中的作用.
主要方法:
- 向小鼠在一天的不同时间 (下午和午夜) 给予LPS.
- 测量了炎症标志物,中性粒细胞活化和生存率.
- 评估了皮质和黑激素水平对免疫反应的影响.
主要成果:
- 与午夜挑战相比,下午的LPS挑战导致中性粒细胞激活的增加,严重的炎症和较高的死亡率.
- 下午的皮质类固醇峰值加剧了LPS诱导的高炎症.
- 午夜的黑激素水平通过减少炎症反应来保护小鼠.
结论:
- 循环节律,特别是激素周期 (皮质和黑激素),显著影响败血症的结果.
- 败血症患者的荷尔蒙特征 (高皮质醇,低黑激素) 与敏感小鼠的荷尔蒙特征相似,这表明一种预后标志物.
- 确定了一个调节网络,将光明/黑暗周期和昼夜激素与感染中的炎症强度联系起来.
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