菌生长决定了病原性多微生物群体在空间结构化的环境中的空间组织和共存
Leonardo Mancini1,2, Laila Saliekh3, Rory Claydon3
1Department of Physics, Cavendish Laboratory, University of Cambridge, J.J. Thomson Avenue, Cambridge, Cambridgeshire CB3 0HE, United Kingdom.
The ISME journal
|December 18, 2025
概括
感染中的微生物群落表现出空间结构. 封闭的微环境允许病原体如Pseudomonas aeruginosa,金黄色葡萄球菌和白菌共存,影响感染的严重程度和治疗.
科学领域:
- 微生物生态学 微生物生态学
- 传染病的发病因子 传染病的发病因子
- 空间生物学 空间生物学
背景情况:
- 宏观生物在不同器官中拥有复杂的微生物群落.
- 器官层面的环境因素与微生物组成和病原体感染有关.
- 微观空间结构在多微生物感染中的作用仍然不太清楚.
研究的目的:
- 研究微观空间结构对多微生物感染生态学的影响.
- 确定 Pseudomonas aeruginosa,金黄色葡萄球菌和白菌在不同空间环境中的共存动态.
- 探索空间组织对病原体竞争和迁移的影响.
主要方法:
- 研究了涉及P. aeruginosa,S. aureus和C. albicans的三种感染的空间生态.
- 对比大面积上的微生物相互作用与空间结构化的微环境.
- 对野生类型的P. aeruginosa和携带mexT失活突变的菌株的评估结果.
主要成果:
- 在大面积上,P. aeruginosa超过了C. albicans和S. aureus的竞争力.
- 空间结构化的微环境促进了强大的空间组织和三种病原体的共存.
- 菌使用放射性菌生长以建立在狭窄的空间,取代其他病原体.
结论:
- 微观空间结构是病原体共存和感染动态的关键决定因素.
- 机械力量和微环境结构极大地影响了感染结果和毒性.
- 这些发现可以将其推广到其他微生物生态中,并表明潜在的治疗点.
相关概念视频
01:29Microbial Morphologies
1.8K
Bacterial and archaeal cells exhibit remarkable diversity in shape and structure, critical in their adaptability and functionality. Among bacteria, the most commonly observed shapes include cocci and bacilli. Cocci are spherical and may exist singly or in groupings such as pairs (diplococci), chains (streptococci), clusters (staphylococci), or tetrads. Bacilli, in contrast, are rod-shaped and can also occur as single cells, in pairs, or chains, depending on their environmental and genetic...
1.8K
01:29Fungal Group Zygomycota
949
Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
949
01:26Bacterial Phylum Planctomycetes
385
Planctomycetes are a group of morphologically distinct bacteria predominantly classified into two orders: Planctomycetales and Brocadiales. These gram-negative bacteria exhibit unique features, including division by budding and the presence of stalks or appendages. Their cells are often found in rosette arrangements, and they are notable for possessing an S-layer in their cell envelope, which is relatively uncommon among bacteria. Additionally, Planctomycetes frequently exhibit intracellular...
385
01:27Diversity of Protists IV
709
Amoebozoa represent a diverse group of terrestrial and aquatic protists that utilize lobe-shaped pseudopodia for locomotion and feeding. This characteristic differentiates them from the Rhizaria, which possess threadlike pseudopodia. The primary classifications within Amoebozoa include gymnamoebas, entamoebas, and the plasmodial and cellular slime molds. Phylogenetic evidence indicates that Amoebozoa diverged from a lineage that ultimately gave rise to fungi and animals.Gymnamoebas and...
709
01:29Biofilms
1.0K
Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
1.0K
01:30Bacterial Phylum Actinobacteria
573
Coryneform bacteria are gram-positive, aerobic, nonmotile rods that exhibit irregular, club-shaped, or V-shaped arrangements. Their V-shape results from snapping division, where the inner cell wall layer forms the cross-wall, while the outer layer remains intact until it ruptures on one side, causing the daughter cells to bend away.The primary genera are Corynebacterium and Arthrobacter. Corynebacterium includes diverse species, ranging from saprophytes to pathogens like Corynebacterium...
573