慢性鼻炎的特征性内型:新兴的研究和临床应用
Steven Chun-Kang Liao1,2, Brooke N Gleason1, Bruce K Tan1,3
1Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Current opinion in otolaryngology & head and neck surgery
|December 18, 2025
概括
慢性鼻炎 (CRS) 的内型确定对于有针对性的生物疗法至关重要. 本综述涵盖了在实施基于内型的护理方面的进展和挑战,强调了其临床相关性.
科学领域:
- 鼻科和免疫学 鼻科和免疫学
- 在呼吸道疾病中的精准医学.
背景情况:
- 内型化,通过免疫学组织炎症,现在对慢性鼻炎 (CRS) 具有临床意义.
- 有针对性的生物疗法已经推进了内型化临床应用.
- 本综述探讨了基于内型的CRS护理的进展和实施挑战.
研究的目的:
- 审查CRS内型鉴定的及时性和相关性.
- 为了突出CRS内型化方面的最新进展.
- 讨论将基于内型的护理整合到临床实践中的挑战.
主要方法:
- 关于CRS内型化近期进展的文献综述.
- 分析不同的内型化方法:细胞,单生物标志物和多生物标志物测试.
- 检查机器学习在内型分类中的应用.
主要成果:
- 患者被分为内型类型,如2型,1/3型,乳腺炎和混合型.
- 内型与临床特征,手术结果和治疗反应相关.
- 基于组织学,单生物标志物和多生物标志物分析是关键的内型化策略.
结论:
- 经过验证的内型对于在CRS中选择适当的精密生物制剂至关重要.
- 标准化,成本效益测试和临床验证对于广泛采用至关重要.
- 每种内型化方法都有独特的优点和局限性,需要仔细考虑.
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