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Updated: Jan 7, 2026

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蛋白质体应激通过RAP2-MAP4Ks-LATS1/2通路激活YAP/TAZ,以及其在固体瘤中的治疗影响

Xin Wang1, Yuan Gu1,2, Zhenxing Zhong1

  • 1Institute of Pediatrics, Children's Hospital of Fudan University, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.

Proceedings of the National Academy of Sciences of the United States of America
|December 18, 2025
PubMed
概括

由于Hippo路径激活,蛋白质酶抑制剂在固体瘤中受到限制. 阻断对相关蛋白 (YAP) /TAZ克服了这种抵抗,为侵袭性癌症提供了一种新的组合治疗策略.

关键词:
河马的路径 河马的路径哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈药物重用是为了改变药物的用途.蛋白质酶体蛋白质组是什么固体瘤是一个固体瘤.

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