哺乳动物外周神经系统的内在神经网络组织
Larry W Swanson1, Joel D Hahn1, Olaf Sporns2
1Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089.
概括
周围神经系统 (PNS) 是一个复杂的网络,不仅仅是简单的神经. 这项研究揭示了PNS内部结构化,相互连接的神经元架构,挑战了传统观点.
科学领域:
- 神经科学是一个神经科学.
- 系统神经科学 系统神经科学
- 计算神经科学是一种神经科学.
背景情况:
- 周围神经系统 (PNS) 传统上被视为中央神经系统 (CNS) 和身体之间的信号通道.
- 它的内部组织和连接模式超出简单的神经通道的理解较少.
研究的目的:
- 分析哺乳动物外周神经系统内的神经解剖连接.
- 描述网络架构,并确定PNS内部连接组的组织原则.
主要方法:
- 在老鼠中,对外围质之间的轴突连接的神经解剖学数据的整理和分析.
- 将集群分析应用于52个质的52x52连接矩阵 (连接组).
- 使用节点中心性指标检查全球网络属性.
主要成果:
- 在52个感官和自主性格里亚之间识别了100多个连接,揭示了稀疏但广泛的PNS内部神经元架构.
- 发现了22个模块,这些模块以六个层次的嵌套层次结构组织,在中央神经系统-身体轴上空间分布.
- 描述两个枢纽 (脑) 和小世界网络的特征,与老鼠大脑相比.
结论:
- PNS拥有结构化且经常连接的神经网络,挑战了平行神经通路的观点.
- 这种PNS内部网络表现出复杂的模块化组织和全球性属性.
- 需要使用结构-功能方法进行进一步的研究,以充分阐明PNS网络的范围和功能意义.
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