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四价人乳头瘤病毒疫苗和高度的性阴道病变

Yunyang Deng¹, Shiqiang Wu^1,2, Lina Schollin Ask^3,4,5

¹Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

|December 18, 2025

概括

人类乳头瘤病毒 (HPV) 疫苗接种显著减少了女性的高度部阴道病变. 早期接种疫苗,特别是在17岁之前,显示出最大的保护作用,支持更广泛的HPV疫苗计划.

科学领域:

妇科妇科妇科妇科
在瘤学瘤学.
疫苗学疫苗学疫苗学

背景情况:

人类乳头瘤病毒 (HPV) 疫苗接种与较少的宫病变有关.
关于HPV疫苗对高度阴部病变的影响的数据有限.

研究的目的:

评估四价HPV疫苗接种与高度的阴部病变之间的关联.
评估在不同疫苗接种计划中人口层面的发病率降低.

主要方法:

瑞典 (2006-2022) 基于人口的队列研究,包括1985-1998年出生的女性.
作为时间变化的暴露,HPV疫苗接种状态,分析高度 vulvovaginal 病变的发生率.
普森回归模型用于计算发病率比率.

主要成果:

在778,943名妇女中,32.9%接受了HPV疫苗接种.
接种疫苗的妇女的高度阴部病变发生率降低了37% (IRR,0.63).
在17岁之前接种疫苗,与17岁以上接种疫苗 (IRR,0.80) 相比,降低了更大的风险 (IRR,0.45).

结论:

HPV 疫苗接种与高度 vulvovaginal 病变的发病率降低有关.
在较年轻的年龄 (<17岁) 接种疫苗可以提供更好的保护.
增加HPV疫苗接种覆盖率,特别是在年轻时,可以帮助预防这些病变.

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