结核病后症状性肺病的解剖学和功能特征
R Perumal1, S Pillay2, N Bagratee3
1Department of Pulmonology and Critical Care, School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa;, CAPRISA-MRC HIV/TB Pathogenesis and Treatment Research Unit, Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.
结核病幸存者经常面临慢性呼吸系统问题,由于持续的肺损伤. 这项研究揭示了结核病后肺部疾病的复杂解剖和功能缺陷,突出了进一步研究的需要.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 放射学 放射学是一门学科.
背景情况:
- 结核病 (TB) 幸存者经常经历治疗后的慢性呼吸道问题.
- 持续的解剖和功能缺陷导致结核病幸存者的长期发病率.
研究的目的:
- 在肺结核治疗后经历持续呼吸道症状的个体中描述解剖学和功能性肺部缺陷.
- 为了研究后结核肺病的复杂性质.
主要方法:
- 对完成结核病治疗的个人进行持续呼吸道症状的查.
- 通过临床面试,肺功能测试,胸部放射,CT扫描,PET扫描和支气管支气管洗进行评估.
主要成果:
- 20.8%的参与者报告了持续的呼吸道症状.
- 肺功能测试显示,在有症状的个体中,分别在25%,15%和20%的个体中出现了限制,阻塞或混合生理.
- CT扫描显示普遍纤维化 (100%),高频率的支气管切除 (75%),和肺结节 (65%),与PET显示[18F]FDG急性病变在75%.
结论:
- 结核病后的肺部疾病的特点是复杂而异质的解剖和功能异常.
- 迫切需要进行强有力的研究,以评估结核病在治疗后的全部影响,特别是在高负担环境中.
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