暴露于和类化合物和与过敏相关的结果之间的关联
Caishan Fang1,2, Xiangjun Qi3, Qinwei Fu1,4
1Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
American journal of rhinology & allergy
|December 18, 2025
概括
暴露于类甲和类 (PAP) 与青少年的过敏风险增加有关,特别是来自三素 (TCS),甲基类甲 (MPB) 和类甲 (PPB). 成年人接触TCS和MPB也显示了与过敏结果的关联.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 流行病学 流行病学
背景情况:
- 和 (PAP) 是消费品中常见的化学物质.
- 关于青少年和成年人的PAP暴露和过敏的证据有限.
研究的目的:
- 检查尿路PAP与青少年和成年人的过敏相关结果之间的关联.
- 为了识别与过敏相关的特定PAP和混合物.
主要方法:
- 对NHANES 2005-2006年数据进行横截面分析.
- 测量了8个尿路PAP,并评估了自我报告的过敏症状和敏感性.
- 用了通用的线性模型和加权量子式总和回归来进行分析.
主要成果:
- 在青少年中,较高的 triclosan (TCS) 与过敏性鼻炎,过敏,鼻感染和打喷有关.
- TCS,甲基 (MPB) 和类 (PPB) 与青少年的灰尘虫敏感性有关.
- 在成年人中,MPB与过敏性鼻炎和打喷有关;TCS与花粉热和植物敏感性有关.
结论:
- 特定的PAP (TCS,MPB,PPB) 和PAP混合物增加了青少年的过敏风险.
- 在成年人中,TCS和MPB显示与过敏结果的积极关联.
- 在成年人中,PAP混合物的总体关联性并不显著.
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