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在磁共振成像中非特异性光神经外增强的频率
Mary V Lang1, Jessica A Kraker, Ajay A Madhavan
1Alix School of Medicine (MVL), Mayo Clinic, Rochester, Minnesota; and Departments of Ophthalmology (JAK, DAT, KDC, JJC), Radiology (AAM, FP), and Neurology (DAT, JJC), Mayo Clinic, Rochester, Minnesota.
概括
在MRI上,视神经外增强 (ONSE) 可能发生在健康个体中,在微妙的视神经疾病中可能会错过. 临床相关性对于准确的ONSE解释至关重要,特别是高场MRI.
科学领域:
- 放射学 放射学是一门学科.
- 神经成像是一种神经成像.
- 眼科医生 眼科 眼科
背景情况:
- 在MRI上,视神经外增强 (ONSE) 是与各种病理相关的发现,但也可能存在于无症状个体.
- 对于ONSE的诊断效用,需要仔细评估其患病率和在区分疾病与正常变异方面的准确性.
研究的目的:
- 为了确定患有和没有视神经病理的患者中ONSE的患病率.
- 评估MRI上ONSE检测的灵敏度和特异性.
- 评估MRI场强度 (1.5T与3T) 和人口因素对ONSE解释的影响.
主要方法:
- 追溯分析115个轨道MRI扫描从患者和没有已知的视神经病理.
- 盲目的神经放射学家对ONSE存在/不存在的审查.
- 根据MRI场强度 (1.5T和3T) 分层的诊断性能指标的计算.
主要成果:
- 对ONSE检测的总体灵敏度为87%,特异性为93%.
- 与1.5T MRI相比,3T MRI显示出更高的灵敏度 (100%),但较低的特异性 (90%),比1.5T MRI (75%的灵敏度,95%的特异性).
- 假阳性发生在7%的对照组中,13%的真实病例被遗漏;年龄,性别和种族没有显著影响检测.
结论:
- ONSE可以存在于无症状的个体中,并且在疾病中可能是微妙的,需要临床相关性.
- 高强度磁场MRI (3T) 可能会提高对病理性ONSE的敏感性,但会带来错误阳性结果的风险.
- 谨慎地解释ONSE是必不可少的,特别是在无症状患者或使用高分辨率成像技术时.
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