重新评估单剂量凯托洛拉克用于初级宫腔整形术术后疼痛管理
Athena Zhang1, Sofia A Finestone1, Jonathan Chestang1
1Division of Plastic and Reconstructive Surgery, Children's National Hospital, Washington, DC, USA.
概括
在初级口腔整形术后,单剂量凯托洛拉克可以改善早期疼痛控制,而不会增加并发症. 这种非类固醇抗炎药物为儿科手术恢复提供了潜在的好处.
科学领域:
- 儿科手术 儿科手术
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
背景情况:
- 宫腔整形是一种常见的儿科手术手术.
- 有效的疼痛管理对于宫腔塑造术后的恢复至关重要.
- 阿片类药物的使用与儿科患者的显著副作用有关.
研究的目的:
- 为了评估一次性术后剂量基托洛拉克 (ketorolac) 在初级宫腔整形 (PP) 后的安全性.
- 评估Ketorolac在减少阿片类药物消费和改善康复指标方面的有效性.
- 为了比较接受和不接受 ketorolac.lac 的患者之间的结果.
主要方法:
- 未来的队列研究与历史的对照在三级儿科医院.
- 124名患者在PP后接受了单次静脉注射剂量的凯托洛拉克;125人没有.
- 安全结果包括出血和氧气需求;有效性结果使用FLACC尺度,阿片类药物使用和口服时间.
主要成果:
- 两组之间没有出血,氧气需求或不良事件的显著差异.
- 凯托洛拉克组在手术后的前4小时内显示出明显较低的FLACC得分.
- 趋势表明,在ketorolac组中,阿片类药物的使用较低,口服摄入较早,住院时间较短.
结论:
- 立即术后单剂量基托洛拉克在初级 palatoplasty 后是安全的.
- 凯托洛拉克可以改善早期的术后疼痛控制,而不会增加并发症的发生率.
- 对于其他观察到的潜在益处,需要进一步研究.
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