"C-反应蛋白与正常张力玻璃眼疾病之间的相关性:元分析"
Yen Thi Thao Le1,2, Shu-Han Chuang3, Duy Nguyen Anh Tran1,4
1International Master Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
European journal of ophthalmology
|December 18, 2025
概括
较高的C-反应蛋白 (CRP) 水平与正常紧张型玻璃眼 (NTG) 有关,这表明炎症起着作用. 这一发现可能有助于识别 NTG 风险较高的个体.
科学领域:
- 眼科医生 眼科 眼科
- 免疫学 免疫学 免疫学
- 心血管疾病 心血管疾病
背景情况:
- 正常张力玻璃眼 (NTG) 是一种流行形式的玻璃眼,其特点是视神经受损和视力丧失,而眼内压力没有升高.
- 系统性炎症和血管功能障碍越来越多地与NTG的病原发生有关.
- C-反应蛋白 (CRP) 是系统性炎症和动脉样硬化的一种成熟标志物,但其与NTG的关联尚未明确.
研究的目的:
- 调查C反应性蛋白 (CRP) 水平与正常张力玻璃眼 (NTG) 之间的关联.
- 为了比较NTG患者和对照患者的CRP水平.
- 评估CRP作为NTG的潜在指标.
主要方法:
- 对观察性研究 (病例控制) 进行了系统的元分析.
- 研究通过对PubMed,Embase和Scopus的全面搜索确定了研究,截至2023年10月31日.
- 来自10项涉及766名参与者的研究数据使用标准化平均差异 (SMD) 和95%置信区间 (CI) 进行了分析.
主要成果:
- 分析显示,与对照人群相比,NTG患者的CRP水平显著更高 (SMD:0.731,P=0.014).
- 在初级开角青光眼 (POAG) 患者和对照组之间没有发现CRP水平的显著差异 (SMD=0.093,P=0.472).
结论:
- 循环中CRP水平升高与NTG显著相关.
- 这表明系统性炎症在NTG的发病过程中可能发挥作用.
- CRP可以作为识别高风险个体的辅助标记,保证进一步的前性研究.
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