雌激素上调乳酸来诱导高凝血性,以在怀孕期间提供血静保护
Ruomei Cheng1, Xiaopeng Tang, Xiaoshan Huang2
1Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Mol, Kunming, China.
Blood
|December 18, 2025
概括
怀孕增加了由于乳二增加的血栓风险,这增强了凝血因子XIa的活性. 在小鼠中用HS9阻断乳费林减少了血栓形成,比肝素出血少.
科学领域:
- 生殖生物学 生殖生物学
- 血液学 血液学 血液学
- 血栓形成的分子机制
背景情况:
- 怀孕是一种高凝血状态,增加了母亲患静脉血栓塞栓症 (VTE) 的风险.
- 怀孕期间这种原血栓转移的精确分子驱动因素尚未完全理解.
研究的目的:
- 为了研究乳酸铁素在与怀孕相关的高凝血性中的作用.
- 确定乳酸铁素作为预防孕妇VTE的潜在治疗标.
主要方法:
- 鉴定出乳酸作为凝血因子XIa (FXIa) 活性增强剂.
- 测量了怀孕妇女的乳酸铁血度,并通过EREs观察了雌激素依赖性.
- 使用乳酸铁素基因淘汰和HS9抑制的小鼠模型.
主要成果:
- 在怀孕期间观察到血中乳酸含量升高,与雌激素有关.
- 遗传或药理上抑制乳酸可以改善小鼠妊娠诱导的血栓形成.
- 与低分子量肝素相比,HS9显示出降低了出血风险.
结论:
- 乳酸是妊娠期高凝血能力的关键生理调节剂.
- 向乳二是一种有前途的策略,用于管理与怀孕相关的VTE.
- 抑制乳托费林可以减轻血栓风险,同时保持血静.
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