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相关概念视频

Dose Size and Dosing Frequency: Determination Methods01:21

Dose Size and Dosing Frequency: Determination Methods

250
Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...
250
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

231
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
231

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相关实验视频

Updated: Jan 8, 2026

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
09:18

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection

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德克萨米他剂量的人类淋巴与使用内耳模拟的常见分娩协议进行比较.

Alec N Salt, Jeremy G Turner

    Audiology & neuro-otology
    |December 18, 2025
    PubMed
    概括

    耳植入物为内耳疾病提供最有效的德甲输送,在最小的全身暴露下达到治疗水平. 其他方法,如入耳内膜注射,其有效性和潜在副作用各不相同.

    科学领域:

    • 耳鼻喉科 耳鼻喉科 耳鼻喉科
    • 药理动力学 药理动力学
    • 生物医学工程 生物医学工程

    背景情况:

    • 局部德克萨米他治疗对于内耳疾病,如Meniere病至关重要.
    • 德甲通过减少电极阻抗和纤维组织来帮助耳植入.
    • 多种配方使得德克萨米他剂量水平的比较变得复杂.

    研究的目的:

    • 通过模拟,量化比较使用德克萨米他输送方法.
    • 为了评估不同剂量方法的经淋巴和血中德克萨米他水平.
    • 为了确定最有效和最安全的德克萨米他输送协议.

    主要方法:

    • 使用了FluidSim耳液体模拟程序.
    • 计算了各种临床剂量策略的周淋巴和血中德克萨米他水平.
    • 采用相同的药理动力学参数用于淋巴和血.

    主要成果:

    • 所有的模拟方案都实现了治疗性临淋巴度,但时间过程不同.
    • 一些方案导致全身血度超过治疗水平,增加副作用的风险.
    • 耳植入物证明了最有效的交付与最小的系统影响.

    结论:

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    A Surgical Procedure for the Administration of Drugs to the Inner Ear in a Non-Human Primate Common Marmoset Callithrix jacchus
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    • 模拟允许对德克萨米他输送协议进行定量比较.
    • 耳植入物在耳中提供了卓越的德克萨米他剂量效率.
    • 螺旋疗法SPT-2101和常规的入耳内甲酸显示出不同的全身暴露特征.