预后营养指数预测心血管代谢综合征的分期和死亡率
Yiying Liu1, Fuyuan Zhang1, Ruikang Liu1
1Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
PloS one
|December 18, 2025
概括
预后营养指数 (PNI) 与心血管--代谢综合征 (CKM) 阶段有关,并预测死亡率. 较高的PNI水平与CKM患者的更好的生存率相关.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 代谢障碍 代谢障碍 代谢障碍
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 心血管--代谢综合征 (CKM) 是一种复杂的疾病,死亡率高.
- 预后营养指数 (PNI) 反映了营养和免疫状况,并预测了结果.
- 了解PNI在CKM进展和预后中的作用至关重要.
研究的目的:
- 研究预后营养指数 (PNI) 与心血管--代谢综合征 (CKM) 的阶段之间的关联.
- 评估PNI作为CKM患者全因和心血管死亡率的预测因素.
主要方法:
- 从1999-2018年NHANES队列中分析了10,448名CKM患者.
- 权重后勤回归和受限立方线来评估PNI与CKM阶段的关系.
- 卡普兰-梅尔和考克斯的比例危险模型来确定PNI与死亡结果的关联.
主要成果:
- 在CKM早期阶段,PNI水平最高,在晚期阶段最低.
- 在PNI和早期CKM阶段之间观察到一个反向的U形关系,在晚期阶段有反向的关联.
- 较高的PNI四分位数与明显较低的全因和心血管死亡风险有关.
- 对所有原因和心血管死亡率分别确定了50和51的PNI值.
结论:
- PNI与CKM的早期和晚期都显著相关.
- 在CKM患者中,PNI独立预测了全因和心血管死亡率.
- PNI可以作为一种有价值的生物标志物,用于CKM中的风险分层和风险管理.
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